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1.
Journal of Korean Academy of Nursing ; : 1175-1182, 2006.
Article in Korean | WPRIM | ID: wpr-212310

ABSTRACT

PURPOSE: This study was conducted to evaluate the effects of stroke patient care education on the knowledge and practice of caregivers of stroke patients. METHOD: Data was collected from December 15, 2004 to March 30, 2005. The research design was a non-equivalent control group non-synchronized design. The subjects were forty primary caregivers of stroke patients who were hospitalized in a neurology unit of a university hospital. Forty caregivers, twenty in the experimental group and twenty in the control group were assigned. The experimental group participated 2 times in an education class given by the researcher. Data analysis included -test, and t-test using the SPSS program. RESULT: Knowledge(t=5..87, p=o.oo) and practice(t=5.53, p=0.00) of the experimental group were significantly different from the control group. CONCLUSION: The stroke patient care education developed in this studyshows a significant promotion of knowledge and practice of caregivers. Thus this program can be recommanded as an intervention model for stroke patients and caregivers.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Caregivers/education , Family , Health Knowledge, Attitudes, Practice , Models, Nursing , Patient Education as Topic , Program Evaluation , Stroke/therapy
2.
Journal of Korean Medical Science ; : 518-526, 2006.
Article in English | WPRIM | ID: wpr-47123

ABSTRACT

Corticotropin releasing factor (CRF) is known to be involved in the stress response and in some degenerative brain disorders. In addition, CRF has a role as a neuromodulator in adult cerebellar circuits. Data from developmental studies suggest a putative role for CRF as a trophic factor during cerebellar development. In this study, we investigated the trophic role for CRF family of peptides by culturing cerebellar neurons in the presence of CRF, urocortin or urocortin II. Primary cell cultures of cerebella from embryonic day 18 mice were established, and cells were treated for either 1, 5 or 9 days with Basal Medium Eagles complete medium alone or complete medium with 1 micrometer CRF, urocortin, or urocortin II. The number of GABA-positive neurons in each treatment condition was counted at each culture age for monitoring the changes in neuronal survival. Treatment with 1 micrometer CRF or 1 micrometer urocortin increased the survival of GABAergic neurons at 6 days in vitro and 10 days in vitro, and this survival promoting effect was abolished by treatment with astressin in the presence of those peptides. Based on these data, we suggest that CRF or urocortin has a trophic role promoting the survival of cerebellar GABAergic neurons in cultures.


Subject(s)
Mice , Animals , gamma-Aminobutyric Acid/metabolism , Time Factors , Receptors, Corticotropin-Releasing Hormone/metabolism , Peptides/chemistry , Neurons/metabolism , Mice, Inbred C57BL , Immunohistochemistry , Image Processing, Computer-Assisted , Corticotropin-Releasing Hormone/biosynthesis , Cerebellum/embryology , Cells, Cultured , Cell Survival
3.
Journal of Asthma, Allergy and Clinical Immunology ; : 662-667, 2001.
Article in Korean | WPRIM | ID: wpr-223980

ABSTRACT

Idiopathic hypereosinophilic syndrome is characterized by multiorgan involvement without any cause, and peripheral eosinophilia(1,500/microliter) for more than 6 months. Clinically, many organs can be involved, but the heart is the most commonly involved organ. Although lung involvement is usual(20-30%)1) in hypereosinophilic syndrome, there are few reports of eosinophilic pneumonia proven by biopsy confirmation in Korea. We experienced a case of hypereosinophilic syndrome with eosinophilic pneumonia and bronchitis confirmed by biopsy, and we report it here with a review of the literature.


Subject(s)
Biopsy , Bronchitis , Eosinophils , Heart , Hypereosinophilic Syndrome , Korea , Lung , Pulmonary Eosinophilia
4.
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons ; : 33-42, 2000.
Article in Korean | WPRIM | ID: wpr-784227
5.
Korean Journal of Anatomy ; : 245-252, 1999.
Article in Korean | WPRIM | ID: wpr-651040

ABSTRACT

Guanine aminohydrolase (GAH; Guanine deaminase, EC 3.5.4.3) is an enzyme that has a role in purine catabolism. This enzyme produces xanthine and ammonia by hydrolysis of guanine, and xanthine is further degraded to uric acid and hydrogen peroxide by another enzyme, xanthine oxidase. Most of the enzymes involved in purine catabolism have been studied for their biological functions, physiological roles and amino acid sequences, and biochemical activity of GAH is known to be detected in various organs such as liver, kidney, small intestine and brain. Its activity is also known to be changed during brain development. In this study, we hoped to reveal expression pattern of GAH in developing rat brain by western blotting and immunohistochemistry. In western blotting, GAH immunoreactivity was not detected on 14-, 16- and 18-days-old fetal rat brains. Its reactivity was first detected from 20-days-old fetal rat brain and highly increased after birth. And it was maintained at steady level from 2 weeks after birth. In immunohistochemistry, no positive cells were found on 14- and 16-days-old fetal rat brain sections. A few GAH-immunoreactive cells appeared from 18-days-old fetal rat brain and they were localized at olfactory bulb, cerebral cortex, midbrain, pons and medulla. The 20-days-old fetal rat brain also showed immunoreactive cells at hippocampus and the staining intensity was still weak. Postnatal 2-days-old rat brain also showed immunoreactive cells at basal ganglia and the number of positive cells and staining intensity were increased. Thereafter, immunoreactivity appeared on many neuronal cells around various areas in the brain and nerve fibers also showed reactivity on postnatal brains. The number of positive cells decreased from 1 week after birth and a few positive cells were observed on olfactory bulb and cerebellum from 2 weeks after birth. In mature brain most of GAH were localized on nerve fibers and few positive cells could be found on olfatory bulb only. From these, we can suspect that GAH may have some functional relationship with nerve fibers.


Subject(s)
Animals , Rats , Amino Acid Sequence , Ammonia , Basal Ganglia , Blotting, Western , Brain , Cerebellum , Cerebral Cortex , Guanine Deaminase , Guanine , Hippocampus , Hope , Hydrogen Peroxide , Hydrolysis , Immunohistochemistry , Intestine, Small , Kidney , Liver , Mesencephalon , Metabolism , Nerve Fibers , Neurons , Olfactory Bulb , Parturition , Pons , Uric Acid , Xanthine , Xanthine Oxidase
6.
Tuberculosis and Respiratory Diseases ; : 311-316, 1999.
Article in Korean | WPRIM | ID: wpr-38124

ABSTRACT

BACKGROUND: The drug-resistant tuberculosis has recently decreased in Korea, but it is still one of the major obstacles in the treatment of pulmonary tuberculosis. Unfortunately there are no reliable ways to figure out the drug sensitivity pattern of the M. tuberculosis in the starting point of treatment. At least several months which is critical for the success of treatment have to be passed away before getting the report of drug-sensitivity test. The aim of this study was to find out the clinical and radiological parameters that make it possible to predict the drug-resistant pulmonary tuberculosis and to make a correct decision on the antituberculosis drug regimens. METHOD: We studied 253 pulmonary TB patients with sputum and/or bronchial washing fluid culture-positive diagnosed at the Chung-Ang University Young-San Hospital in the period of 1989-1994. The differences in the clinical and raiological variables between the drug-sensitive and the drug-resistant tuberculosis patients were evaluated. RESULTS: In 66 out of 253 patients(26.1%), drug resistant tuberculosis to at least one antituberculosis drug were found. Patients with retreatment showed higher resistance rate than those with initial treatment (30/69,43.5% vs 36/184, 19.5%, p<0.01). Patients with cavitary TB showed higher resistance rate than those with non-cavitary TB( (24/54, 44.4% vs 42/199, 21.1%, p<0.05). Among patients with initial treatment, those with far-advanced TB showed a higher drug resistance rate than those with minimal lesion(9/23, 36.9% vs 10/82, 12.5%, p<0.05). Patients with culture positive only in the bronchial washing fluid showed lower resistance rate than those with sputum culture positive(7/63, 11.1% vs 59/190, 31.1%, p<0.05) CONCLUSION: Prior treatment history for pulmonary tuberculosis, the presence of cavity & far advanced tuberculosis in the radiologic exam, sputum rather than solely bronchial washing culture positivity would be the related factors to the drug resistance. So in the patients with such characteristics, it is needed to try to find out the drug sensitivity pattern of the infecting tuberculosis organism as soon as possible.


Subject(s)
Humans , Drug Resistance , Korea , Retreatment , Sputum , Tuberculosis , Tuberculosis, Multidrug-Resistant , Tuberculosis, Pulmonary
7.
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 182-186, 1999.
Article in Korean | WPRIM | ID: wpr-48394

ABSTRACT

The Osteoma is a benign tumor characterized by proliferation of compact or cancellous bone, that may form peripherally in a periosteal location or in a central position. The most common site of peripheral osteoma in craniofacial area is the frontal sinus, but rare in the maxillary sinus. Clinically, this lesion that shows slow growing without symptoms can produce swelling and cause asymmetry. This tumor may arise at any age, but slightly more frequently in men than in women, and more common in young age. Radiographically, this lesion appears as a well-circumscribed radiopacity and histopathologically shows proliferation of either compact or cancellous bone. The etiology of ostemas in the paranasal sinus is unknown, but it has been suggested that they are frequently associated with infection and trauma, and in a certain cases are believed to develop in sinus polyps, which are an inflammatory reaction. The treatment of osteoma is surgical excision, but need not be excised unless it causes obstruction to a sinus cavity or disturbing cosmetically, and this tumor usually does not recur after surgical removal. We report a case of peripheral osteoma on the maxillary sinus in 46 male-patient who came our hospital for discomfort of the left cheek and TMJ area.


Subject(s)
Female , Humans , Male , Cheek , Frontal Sinus , Maxillary Sinus , Osteoma , Polyps , Temporomandibular Joint
8.
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons ; : 101-105, 1998.
Article in Korean | WPRIM | ID: wpr-784128
9.
Journal of Asthma, Allergy and Clinical Immunology ; : 466-472, 1998.
Article in Korean | WPRIM | ID: wpr-197004

ABSTRACT

BACKGROUND: Serum eosinophil cationic protein(ECP) level has been proposed as a indirect marker of eosinophilic inflammation of the airway in bronchial asthma. OBJECTIVE: To evaluate serum ECP against indirect clinical markers of disease, we compared bronchial obstruction, bronchial hyperresponsiveness and peripheral blood eosinophil counts, total IgE with serum ECP levels in patients with bronchial asthma and normal controls. METHOD: Fourty-two patients with bronchial asthma and twenty-six normal controls were enrolled. Measurement were made by spirometry, inhalation challenge with methacholine, peripheral blood eosinophil counts, total IgE and FEIA(fluoroenzymatic immunoassay) of serum ECP RESULT: Serum ECP levels were significantly higher in asthmatic patients than normal controls(p<0.0,5). Serum ECP levels were correlated with peripheral blood eosinophil counts(p<0.01, r=0.544) and bronchial hyperresponsiveness(PC,)(p<0.01, r=-0.456) in patients with bronchial asthma. Serum ECP levels were correlated with degree of bronchial obstruction(FEV, % to predicted value, FEV1/FVC%) in total subjects, but not in asthmatic patients. CONCLUSION: Serum ECP level may be used as indicator of disease activity in bronchial asthma and be helpful in differentiation between normal person and asthmatic patients on simple serological method. Further studies on the changes of serum ECP levels according to disease course and therapeutic responses are needed.


Subject(s)
Humans , Asthma , Biomarkers , Eosinophil Cationic Protein , Eosinophils , Immunoglobulin E , Inflammation , Inhalation , Methacholine Chloride , Spirometry
10.
Korean Journal of Medicine ; : 847-853, 1998.
Article in Korean | WPRIM | ID: wpr-176314

ABSTRACT

Bronchial asthma is a chronic airway inflammation disorder involving lymphocyte activation and various cytokines secretion by lymphocyte. The inflammatory response results from a complex network of interactions between inflammatory cells (mast cells, eosinophils, macrophages) and resident cells belonging to the lung structure itself like EC, fibroblasts, or bronchial epithelial cells. IL-6 which is known to up-regulate the endothelial cell expression of adhesion molecules participating in the development of the inflammatory reaction in bronchial asthma is produced by alveolar macrophage. ICAM-1 is produced by bronchial epithelial cell and expression by endothelial cell, which is known to enhance of the influx of various cells. RANTES which is known to a potent chemoattractant for eosinophils, lymphocytes, and monocytes, a member of the CC chemokine family, is expressed by bronchial epithelial cell. To evaluate whether markers of lymphocyte activation are useful markers of disease activity in bronchial asthma, we measured sIL-6, sICAM-1, sRANTES in 42 patients with mild to moderate bronchial asthma and in 26 normal controls and compared the result with other disease activity markers in asthma (pulmonary function, blood eosinophil counts). The mean level of sIL-6 was higher than that of normal control and correlated significantly with sICAM-1, FEV1% to predicted value. The mean level of sICAM-1 was higher than that of normal control and correlated significantly with FEV1%, FEV1% to predicted value. The mean level of sRANTES showed the tendency to be higher than that of normal control, but not significant statistically, and did not correlated with sIL-6, sICAM-1, FEV1%, FEV1% to predicted value, blood eosinophil counts. It appeared that sIL-6 and sICAM-1 could be a disease marker in bronchial asthma. But, clinical application of the measurement of these markers needs to be studied further.


Subject(s)
Humans , Asthma , Chemokine CCL5 , Cytokines , Endothelial Cells , Eosinophils , Epithelial Cells , Fibroblasts , Inflammation , Intercellular Adhesion Molecule-1 , Interleukin-6 , Lung , Lymphocyte Activation , Lymphocytes , Macrophages, Alveolar , Monocytes
11.
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 241-245, 1998.
Article in Korean | WPRIM | ID: wpr-161611

ABSTRACT

Aggressive fibromatosis is best difined as a group of non-encapsulated, non-metastasizing fibrous tumors that have tendency for local recurrence. This tumor is chariaterized histologically by fibroblastic proliferation and clinically by the potential to infiltrate and to recur after surgical excision, but not metastasize. The most common anatomic location have been the abdominal muscle and the extrimities. The incidence of the head and neck is mentioned as from 9.5% to 50% of all desmoid tumors. Within this area, 40%-to 80% of the tumors are located in the neck, but rare in oral cavity. Histologically the tumor is composed of proliferative fibroblasts with a collagenous component. The degree of cellularity varies from area to area and from tumor to tumor. The cells are usually spindle-shaped and the nuclei present only slightly polymorphism, but mitosis are rare and never atypical. Oral fibromatosis has been described as fibrosarcoma, pseusarcoma, pseudosarcomatous fibrosarcoma, metastasizing fibromatosis, juvenile aggressive fibromatosis, and aggressive fibromatosis, but Wilkin and Waldron suggested that the aggressive fibromatosis was a more appropriate term, reflecting the invasive characteristics of the tumor. The treatment of aggressive fibromatosis is traditionally surgical resection with an area of tumor free tissue. But when the complete surgical excision is not possible, radiation and chemotherapy also can be used. Clinically the tumor reported to be not painful in most cases, but capable of rapid growth. Careful clinical and histological examinations are essential for correct diagnosis. We report a case of aggressive fibromatosis. Occurring of the maxilla in 10 year female patient.


Subject(s)
Female , Humans , Abdominal Muscles , Collagen , Diagnosis , Drug Therapy , Fibroblasts , Fibroma , Fibromatosis, Aggressive , Fibrosarcoma , Head , Incidence , Maxilla , Mitosis , Mouth , Neck , Recurrence
12.
Korean Journal of Allergy ; : 250-259, 1997.
Article in Korean | WPRIM | ID: wpr-193863

ABSTRACT

To evaluate the effect of allergic parameters, such as serum IgE, eosinophil, and skin test on the bronchial hyperresponsiveness (BHR) in patients with chronic airflow obstruction, we performed methacholine bronchial provocation test, pulmonary function test, skin prick test, and measured blood eosinophil counts and serum IgE level from seventy-nine patients who showed persistent fixed airflow obstruction, less than 75% of predicted value in FEV~ and FEV1/FVC, despite of conventional treatment without steroid therapy for more than 3 months. The results were as follows 1) There were 53 patients with BHR and 26 patients without BHR. There were no statistically significant differences in sex, age, and smoking duration between positive BHR group and negative BHR group (p>0.05). 2) There was no statistically significant difference in absolute and predicted value of FVC(p>0.05). But there were significantly lower absolute, predicted value of FEV1 and FEV1/FVC% in positive group compared with negative group (p 0.05 ). 4) Blood eosinophil count was significantly higher in positive group than in negative group(p<0.05). Conclusion of this study is that increased bronchial responsiveness in patients with chronic airflow obstruction is inversely related to the level of pulmonary function and significantly associated with blood eosinophilia.


Subject(s)
Humans , Bronchial Provocation Tests , Eosinophilia , Eosinophils , Immunoglobulin E , Methacholine Chloride , Pulmonary Disease, Chronic Obstructive , Respiratory Function Tests , Skin , Skin Tests , Smoke , Smoking
13.
Tuberculosis and Respiratory Diseases ; : 154-161, 1997.
Article in Korean | WPRIM | ID: wpr-166837

ABSTRACT

BACKGROUND: Although the long term adverse effects of cigarette smoking on health are well known, the acute possible detrimental effects of smoking on pulmonary or cardiovascular function, especially when these systems are stressed by the metabolic demands of exercise, have not been well studied. The purpose of this study is to .determine the acute action of cigarette smoking on cardiopulmonary function under stress.' METHOD: Twenty-one healthy smoking subjects were studied. Before exrecise testing, history taking, physical examination and baseline studies, including CBC, chest PA, PFT and EKG, were done. The subjects performed an incremental bicycle exercise test to exhaustion on two occasions, one without smoking and the other after smoking 5 cigarettes/h for 2 hours. All indices of P.F.T and bicycle ergometry were compared between before and after smoking. RESULTS: 1. VO2max and O2 pulse showed significant decrease in smoking day. 2. Although there were no significant differences, anaerobic threshold showed a tendency of decrease and HRmax showed that of increase in smoking day. 3. P.F.T. and respiratory indices showed no significant change in smoking day. CONCLUSION: Cigarette smoking has immediate adverse effect, especially on the cardiovascular system rather than the respiratory system. These results would be due to the effect of elevated HbCO and/or impaired blood flow iii response to the exercise stimulus.


Subject(s)
Humans , Young Adult , Anaerobic Threshold , Cardiovascular System , Electrocardiography , Ergometry , Exercise Test , Physical Examination , Respiratory System , Smoke , Smoking , Thorax , Tobacco Products
14.
Korean Journal of Medicine ; : 1-6, 1997.
Article in Korean | WPRIM | ID: wpr-172746

ABSTRACT

OBJECTIVES: Although DSCG protects against the stimuli of various bronchoconstictor, such as exercise, it is not effective to all patients. There seems to be no therapeutic predictor that determines effectiveness of DSCG on bronchial asthma. Although it is commonly assumed that children with predominantly allergic asthma have a better response to DSCG therapy than adult patient, this has not been convincingly demonstrated, and even adult with late onset nonallergic asthma may benefit. In this study, we evaluated the factors that potentially influenced the ability of DSCG to reduce bronchial hyperresponsibility. METHODS: The treatment groups were sub-divide into effective group(n=14) and ineffective group(n=6) on the basis of significant improvement of followedup PC20 after long term therapy of DSCG. We compared clinical and laboratory data and pulmonary function test between two groups. RESULTS: 1) Disease durtion and pre-treatment pulmonary function (FEV1% predicted, FVC% predicted value) may play a role in determining effectiveness of DSCG on bronchial asthma(p0.05). CONCLUSION: These results show that DSCG is effective in adult chronic asthma and early administration of DSCG, good pulmonary function test and allergic rhinitis history may lead to more favorable outcome.


Subject(s)
Adult , Child , Humans , Asthma , Cromolyn Sodium , Eosinophils , Immunoglobulin E , Respiratory Function Tests , Rhinitis , Skin Tests
15.
Tuberculosis and Respiratory Diseases ; : 1094-1104, 1997.
Article in Korean | WPRIM | ID: wpr-183735

ABSTRACT

BACKGROUND: Spontaneous pneumothoraces(SP) are divided into primary spontaneous pneumothoraces(PSP) which develop in healthy individuals without underlying pulmonary disorders and secondary spontaneous pneumothoraces(SSP) which occur in those who have underlying disorders such as tuberculosis or chronic obstructive lung diseases. Yet there is no established standard therapeutic approach to this disorder, i.e., from the spectrum of noninvasive treatment such as clinical observation with or without oxygen therapy, to aggressively invasive thoracoscopic bullectomy or open thoracotomy. Although chest tube thoracostomy has been most widely used, the patients should overcome pain in the initiation of tube insertion or during indwelling it potential infection and subcutaneous emphysema. Thus smaller-caliber tube has been challenged for the treatment of pneumothorax. Previously, we studied the therapeutic efficacy of 8 French catheter for spontaneous pneumothorax. But there has been few data for effectiveness of small-caliber catheterization in comparison with that of chest tube. In this study, we intended to observe the long-term effectiveness of 8 French catheter for the treatment of spontaneous pneumothoraces in comparison with that of chest tube thoracostomy. METHODS: From January, 1990 to January, 1996, sixty two patients with spontaneous pneumothoraces treated at Chung-Ang University Hospital were reviewed retrospectively. The patients were sub-divided into a group treated with 8 French catheter(n=23) and the other one with chest tube insertion(n=39). The clinical data were reviewed(age, sex, underlying pulmonary disorders, past history of pneumothorax, size of pneumothorax, follow-up period). And therapeutic effect of two groups was compared by treatment duration(duration of indwelling catheter or tube), treatment-associated complications and recurrence rate. RESULTS: The follow-up period(median) of 8 French catheter group and chest tube group was 28 and 22 months, which had no statistical significance. Their was no statistically significant difference of clinical characteristics between two groups with SP, PSP, SSP. The indwelling time of 8 French catheter group was 6.2+/-3.8 days, which was significantly shorter than that of chest tube group in SP, 9.1+/-7.5 days(p=0.047). In comparison of treatment-related complication in PSP, 8 French catheter group as 6.25% of complication showed lower tendency than the other group as 23.8% (p= 0.041 ; one-tailed, p=0.053 ; two-tailed). The recurrence rate in each group of SP was 17.4%, 10.3%, which did not show any statistically significant difference. CONCLUSION: Treatment with 8 French catheter resulted in shorter indwelling time in sponteous pneumothorax, and lower incidence of treatment-related complication in primary spontaneous pneumothorax. And the recurrence rate in each of treatment group showed no statistically significant difference. So, we can recommend the 8 French small-caliber catheter for the initial therapy for spontaneous pneumothorax for the replacement of conventional chest tube thoracostomy. But further prospective study with more subjects of spontaneous pneumothorax will be needed for the evaluation of effectiveness of 8 French cateter.


Subject(s)
Humans , Catheterization , Catheters , Catheters, Indwelling , Chest Tubes , Follow-Up Studies , Incidence , Lung Diseases, Obstructive , Oxygen , Pneumothorax , Recurrence , Retrospective Studies , Subcutaneous Emphysema , Thoracostomy , Thoracotomy , Tuberculosis
16.
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 145-151, 1997.
Article in Korean | WPRIM | ID: wpr-64056

ABSTRACT

Bednar tumor was described by Bednar in 1957. The histologic pattern of this tumor shows similar to dermatofibrosarcoma protuberans (DFSP) but melanin pigments are scattered within the tumor, It's rare neoplasm accounting for approximately 1-5% of all case of DFSP. Clinically, this tumor is considered to be intermediated malignancy, because of slow growth and frequent local recurrence and lack of distant metastasis. The majority are located on the trunk and the upper and lower extremities, but extremely rate in the head and neck area. Microscopically, this tumor is characterized by tight storiform spindle cells and long slender cells that admixed with a small population of melanin containing dendritic cells. This dendritic cells are the primary features distinguising this lesion from conventional DFSP. Complete surgical excision and close follow-up case are necessany for this neoplasm because of probable intermediate malignancy. A patient was admitted to Our Department of Oral and Maxillofacial Surgery due to swelling on right parotid area and numbness of the right lower lip on September, 1994, By clinical examinations and C-T finding, we dignosed tentatively as myxoma or pleomorphic adenoma. Surgical excision of this tumor was performed with parotidectomy and mandibular osteotomy under the frozen biopsy. By final microscopic and electromicroscopic examination and immunohistochemical study, this tumor was diagnosed as Bednar tumor. So, we report a case of pigmented DFSP with review of literatures.


Subject(s)
Humans , Adenoma, Pleomorphic , Biopsy , Dendritic Cells , Dermatofibrosarcoma , Follow-Up Studies , Head , Hypesthesia , Lip , Lower Extremity , Mandibular Osteotomy , Melanins , Myxoma , Neck , Neoplasm Metastasis , Recurrence , Surgery, Oral
17.
Tuberculosis and Respiratory Diseases ; : 852-861, 1996.
Article in Korean | WPRIM | ID: wpr-208494

ABSTRACT

Background: Many clinicians have experienced the difficulty of decision on termination of antituberculosis chemotherapy after the 6th month due to relapse of disease. There is still controversy in the effect of 2S(K)HRZ/4HRZ 6-month short course chemotherapy including pyrazinamide for 6 months in patients with pulmonary tuberculosis. And there is no long term follow-up study of 6-month short course chemotherapy for pulmonary tuberculosis in korea. So we had performed the study to find the result of 6-month antituberculosis chemotherapy for 4 years. Method: We studied prospectively the effect of 2S(K)HRZ/4HRZ in one hundred-fifty patients with pulmonary tuberculosis and followed up fifty-nine patients for more than 1 year to 4 years after the completion of 6-month short course therapy. Results: 1) Out of one hundred-fifty patients, seventy-two patients(48%) completed the prescribed 6-month chemotherapy. Sixty-eight patients(45.3%) have experienced premature discontinuation and the most common cause of premature discontinuation was drop-out against advice(thirty-six patients, 24%). Ten patients(6.7%) were treated beyond the 6 months mainly due to irregular treatment. 2) Fifty-nine patients(81.9%) among seventy-two patients with completed treatment have been followed up for more than 1 year and 32 patients(44.4%) for more than 4 years. There was three relapse patients of whom two patients have experienced relapse of pulmonary tuberculosis within 1 year after the termination of chemotherapy. 3) Among one hundred-thirty-four patients who have been assessible for more than two months of chemotherapy, including the patients who experienced within 2 months, there were eighty-two patients(61.2%) who have experienced adverse reactions and the treament regimen was changed only in thirteen patients(9.7%). The most frequent cause of adverse reactions was arthralgia and/or hyperuricemia, which had occurred in 33 patients(24.6%). Conclusion: In a university hospital in Korea, 6-month short course chemotherapy of 2S(K)HRZ/4HRZ had unnegligible relapses and premature discontinuation. Therefore, change of the regimen might be carefully considered by drug susceptibility results. Close monitoring of patients, retrial of sputum exam and radiologic evaluation during treatment might be required in the endemic area of drug resistant strains like in Korea. Further study about the effect of 6-month short course chemotherapy including pyrazinamide for 6-month might be needed.


Subject(s)
Humans , Arthralgia , Drug Therapy , Follow-Up Studies , Hyperuricemia , Korea , Prospective Studies , Pyrazinamide , Recurrence , Sputum , Tuberculosis, Pulmonary
18.
Tuberculosis and Respiratory Diseases ; : 410-419, 1996.
Article in Korean | WPRIM | ID: wpr-112111

ABSTRACT

BACKGROUND: Spontaneous pneumothorax have been managed with a variety of methods. The technique most frequently used is chest tube drainage. Small caliber catheters were first used in the management of pneumothorax complicating the percutaneous needle aspiration lung biopsy, and the try to treat spontaneous pneumothorax also has been reported. However, the value of small caliber catheters in spontaneous pneumothorax has not been fully evaluated. So, we tried to elucidate the efficacy of 8 French catheter in the management of spontaneous pneumothorax. METHOD: From January, 1990, to April, 1994, 44 patients with spontaneous pneumothorax treated at Chung-Ang university hospital were reviewed. The patients were sub-divide into 8 French catheter insertion group (n=21) and chest tube insertion group (n=23). We compared the presence of underlying lung disease, the extent of the collapse, the duration of indwelling catheter and complication between two groups. RESULTS: 1) The duration of indwelling showed no significant difference between 8 French catheter group and chest tube. But, complication after insertion as subcutaneous emphysema was developed in only chest tube group. (p<0.05) 2) In the primary spontaneous pneumothorax, all case of the pneumothorax of which size was less than 50% showed complete healing with 8 French catheter insertion. Whereas the success rate in patients with large pneumothorax (more than 50%) was tended to be dependent on the age. 3) In the patients with secondary spontaneous pneumothorax who were managed with 8 French catheter, the success rate was trended to be high if the underlying disease of pneumothorax was not COPD and if the patient was young. CONCLUSION: These results show that 8 French catheter insertion probably was effective in the pneumothorax less than 50%, the primary spontaneous pneumothorax, young age or secondary pneumothorax not associated with COPD.


Subject(s)
Humans , Biopsy , Catheters , Catheters, Indwelling , Chest Tubes , Drainage , Lung , Lung Diseases , Needles , Pneumothorax , Pulmonary Disease, Chronic Obstructive , Subcutaneous Emphysema , Thorax
19.
Journal of the Korean Ophthalmological Society ; : 69-79, 1990.
Article in Korean | WPRIM | ID: wpr-199803

ABSTRACT

The characteristics of ocular injury is that the extent of visual disturbance is variable and serious in spite of inconsiderable trauma. Moreover, the prognosis of ocular injury in infancy and childhood is poorer than that in adulthood because the visual funjction of infants and children has not completely matured yet. And the visual disturbance will influence unfavorably upon the selection of occupation in future. Therefore, further investigation of pediatric ocular injuries is thought to be necessary for the establishment of measures of treatment and prevention. The authors clinically analysed 161 eyes of 152 pediatric ocular injurise under the age of 15 year-old who visited emergency room of Masan Koryo General Hospital during the 3 years from January 1, 1986 to December 31, 1988. The ambulation rate of pediatric ocular injuries was 7.5% of total eye patients through emergency room and the incidence was higher in male. The most common disease of all pediatric ocular injuries was lid laceration, followed by subconjunctival hemorrhage and traumatic hyphema. It was revealed that the age group from 4 to 6 was the most hazardous stage for pediatric ocular injuries and a pierced wound by sharp pointed materials was the most harmful and the most dangerous mode of injury.


Subject(s)
Adolescent , Child , Humans , Infant , Male , Emergencies , Emergency Service, Hospital , Hemorrhage , Hospitals, General , Hyphema , Incidence , Lacerations , Occupations , Prognosis , Walking , Wounds and Injuries
20.
Journal of the Korean Ophthalmological Society ; : 459-464, 1989.
Article in Korean | WPRIM | ID: wpr-223014

ABSTRACT

Sturge-Weber syndrome is a congenital disorder characterized by facial nevus flammeus along the distribution of the trigeminal nerve, ipsilatal leptomeningioma, buphthalmos, and choroidal angioma. The Authors experienced a case of Sturge-Weber syndrome in 9 year old female patient and glaucoma was controlled by trabecuectomy without any complications.


Subject(s)
Child , Female , Humans , Choroid , Congenital, Hereditary, and Neonatal Diseases and Abnormalities , Glaucoma , Hemangioma , Hydrophthalmos , Port-Wine Stain , Sturge-Weber Syndrome , Trigeminal Nerve
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